Frontiers in DNA Repair

Berlin, September 12^th 2016

Frontiers in DNA Repair

Berlin, September 12^th 2016

about

DNA repair is a fundamental aspect of DNA metabolism. The inability to properly cope with DNA damage is responsible for a wide spectrum of disorders ranging from developmental and neurological defects to immunodeficiencies and premature aging. Moreover genome instability is a hallmark of cancer genomes and in many cases, the driving force of carcinogenesis.

Since the initial discovery of the intrinsically unstable nature of the DNA molecule and the pioneering work by the 2015 Nobel Prize winners in Chemistry, Lindahl, Modrich and Sancar, the field has witnessed an explosion of findings with implications across multiple disciplines, including cell signaling, chromatin dynamics, transcription, immunology, and cancer biology. This symposium brings together the leading scientists in DNA repair to highlight the most recent advancements in this exciting field.

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Speakers

Titia de Lange, Keynote

The Rockefeller University, New York, USA

Telomeres & the DNA damage response

Thomas Helleday

Karolinska Institute, Stockholm (Sweden)

DNA damage & repair in Cancer

Jiri Lukas

The Novo Nordisk Foundation Center for Protein Research, Copenhagen (Denmark)

Chromosomal Dynamics & Cancer

Michael Lisby

University of Copenhagen, Copenhagen (Denmark)

Cell biology of DNA repair

Anja Groth

BRIC, Copenhagen (Denmark)

Transmission of Epigenetic information during Cell Division

Steve Jackson

Cancer Research UK, Cambridge (UK)

Genome Integrity in Physiology and Disease

Lorraine Symington

Columbia University, New York (USA)

Genetics and Biochemistry of DNA recombination and repair

Andrés Aguilera

Cabimer, Sevilla (Spain)

Transcription-associated Genome Instability

Program

8:00 – 9:00

Registration & Welcome Coffee

9:00 – 9:15

Welcome & Introduction

9:15 – 10:45

Session I − To break or not to break
Chair: Svend Petersen-Mahrt

9:15 – 10:00

Titia de Lange – Keynote Lecture
How shelterin solves the telomere end-protection problem

10:00 – 10:15

Katrin Paeschke (Short Talk)
Mms1 binds to G-quadruplex structures in vivo to regulate replication and genome stability

10:15 – 10:45

Michael Lisby
Mte1/ZGRF1 – a novel regulator of genome stability and telomere maintenance

10:45 – 11:15

Coffee Break & Poster pre-viewing

11:15 – 12:30

Session II − The complex task of maintaining Genome Integrity
Chair: Ylli Doksani

11:15 – 11:45

Jiri Lukas
Endogenous DNA damage: How cells deal with unavoidable

11:45 – 12:00

Bruno Vaz (Short Talk)
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

12:00 – 12:30

Lorraine Symington
Xrs2-dependent and independent functions of the Mre11-Rad50 complex

12:30 – 14:30

Lunch Break & Poster Session

14:30 – 15:45

Session III − DNA damage within a context
Chair: Claudia Lukas

14:30 – 15:00

Anja Groth
Chromatin Replication: A histone reader based mechanism to identify post-replicative chromatin

15:00 – 15:15

Jan Padeken (Short Talk)
Histone H3K9me mediated repression is dispensable for C. elegans development, but suppresses RNA:DNA hybrid-associated repeat instability

15:15 – 15:45

Andrés Aguilera
Role of Chromatin and the DNA damage response in RNA-mediated genome instability

15:45 – 16:15

Coffee Break

16:15 – 17:30

Session IV − Harnessing the DNA damage Response
Chair: Clemens Schmitt

16:15 – 16:45

Steve Jackson
Cellular responses to DNA damage: from mechanistic insights to cancer therapies

16:45 – 17:00

Sounak Sahu (Short Talk)
Molecular mechanism of radiation sensitivity in Planarian stem cells

17:00 – 17:30

Thomas Helleday
Poisoning cancer with oxidized nucleotides by targeting MTH1

17:30 – 18:00

Poster Award & Final Remarks

18:00 – 19:30

Reception

Program might be subjected to changes.

Registration

The Registration is now closed.

Student

75 EUR

Delegate

150 EUR

Registration Fee includes:

Full access to conference
Coffee/Tea breaks, lunch, and reception
Conference bag with abstract book and program
Right to one poster presentation

Abstract & Poster presentation

Submission of an abstract for poster presentation is highly recommended. Abstracts will be included in the symposium booklet, and posters will be reviewed for “Best Poster Award” selection, which will be announced at the end of the symposium.

Abstracts must be submitted online at the time of registration. The “acceptance notice” will be sent via e-mail to the contact author together with the poster requirements.

Short talks

Up to four participants will be selected for short talk presentations based on the submitted abstracts (maximum one short talk presentation per symposium session). Selected participants will be notified by email.

Payment

Registration fee can be paid via Credit Card or PayPal. Successful registration will be confirmed via e-mail to the address provided.

Number of participants will be limited. Early registration is recommended.

Venue & Location

Berlin-Brandenburg Academy of Science and Humanities
Jägerstraße 22/23
Entrance Markgrafenstraße 38
10117 Berlin

The Symposium takes place in the Berlin-Brandenburg Academy of Science and Humanities. The Academy is an interdisciplinary society whose origins trace back to the Society of Sciences of the Elector of Brandenburg founded in 1700. The Academy is located in the heart of Berlin close to the famous Gendarmenmarkt, which thanks to its unique architectural composition with the concert hall, German and French cathedrals, is one of the most beautiful squares in the city.

How to reach the Venue

The venue in central Berlin is easy to reach by the two Berlin airports Tegel and Schönefeld, central train station and public transport.

By Plane:

From Airport Schönefeld: Take the S9 to S+U Schönhauser Allee, change there to line U2 in direction to Ruhleben and get off at Hausvogteiplatz. From there it’s just 350 meters to walk to the venue. Please note that your public transportation ticket must be valid for areas ABC.

From Airport Tegel: Take the JetExpressBus TXL to Unter den Linden/Friedrichstraße. From there it’s 650 meters to walk to the Academy.

Take JetExpressBus X9 to Ernst-Reuther-Platz where you take the U2 with direction to Pankow and get off at Hausvogteiplatz. From there it’s just 350 meters to walk to the venue.

By Train:

From Berlin Hauptbahnhof (Central Station) / Berlin Zoologischer Garten: Take the S5, S7 or S75 to Friedrichstraße and change there to the line U6 in direction to Alt-Mariendorf and get off at Französische Straße. From there it’s 400 meters to walk to the Academy.

From Berlin Ostbahnhof: Take the S5, S7 or S75 to Alexanderplatz, change there to line U2 in direction to Ruhleben and get off at Hausvogteiplatz. From there it’s just 350 meters to walk to the venue.

By Public transport:

Underground: Take line U6 and get off at Französische Straße or take line U2 and get off at Hausvogteiplatz.

S-Bahn: Take line S1, S2 and S25 and get off at Friedrichstraße

Bus: Take the TXL, 100 or 200 bus and get off at Staatsoper

By Car:

Please note that parking in the streets is very limited and stopping zones might be in force. Parking Facilities around the Academy:

Underground Parking Garage Friedrichstadtpassagen, Taubenstraße / Jägerstraße

Underground Parking Garage Hotel Hilton, Mohrenstraße

Underground Parking Garage Unter den Linden / Staatsoper, entrance to car park in Behrenstraße

Hotels

We recommend all participants to arrange their accommodation in Berlin as early as possible.
Fall is a high event season in Berlin and hotels will be booked early. A list of hotels is suggested below:

The Westin Grand Berlin
http://www.westin-berlin.com/

NH Berlin Mitte (Leipziger Strasse):
http://www.nh-hotels.com/hotel/nh-berlin-mitte

NH Collection Berlin Friedrichstrasse (Friedrichstrasse):
http://www.nh-collection.com/hotel/nh-collection-berlin-friedrichstrasse

Arcotel John F Berlin
http://www.arcotelhotels.com/en/john_f_hotel_berlin/